Parkinson's: A Disease of Aberrant Vesicle Trafficking

Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinsons disease

Amy R. Dunn, Kristen A. Stout, Minagi Ozawa, Kelly M. Lohr, Alison I. Bernstein, Yingjie Li, Minzheng Wang, Carmelo Sgobio, Namratha Sastry, Huaibin Cai, W. Michael Caudle, and Gary W. Miller* 1. Rollins School of Public Health, Emory University, Atlanta, GA 30322. 2. Center for Neurodegenerative Disease, Emory University, Atlanta, GA 30322. 3. Transgenics Section, Laboratory of Neurogenetics, ...

LRRK2 and vesicle trafficking.

Mutations in LRRK2 (leucine-rich repeat kinase 2) (also known as PARK8 or dardarin) are responsible for the autosomal-dominant form of PD (Parkinson's disease). LRRK2 mutations were found in approximately 3-5% of familial and 1-3% of sporadic PD cases with the highest prevalence (up to 40%) in North Africans and Ashkenazi Jews. To date, mutations in LRRK2 are a major genetic risk factor for fam...

Exercise-Regulated Vesicle Trafficking

Vesicle Trafficking: A Rab Family Profile

A new tool-kit has been developed for profiling expression and function of Rab GTPases on a genome-wide scale. Use of this tool-kit has revealed unexpectedly that at least half of Drosophila Rabs have neuronal-specific expression patterns and localize to synapses.

Vesicle trafficking from a lipid perspective

The protein cargo transported by specific types of vesicles largely defines the different secretory trafficking pathways operating within cells. However, mole per mole the most abundant cargo contained within transport vesicles is not protein, but lipid. Taking a "lipid-centric" point-of-view, we examine the importance of lipid signaling, membrane lipid organization and lipid metabolism for ves...